180 Life Sciences Announces Publication of a Review on the Biological Basis of Dupuytren’s Disease
PALO ALTO, Calif., January 4, 2023 -- 180 Life Sciences Corp. (NASDAQ: ATNF) (“180 Life Sciences” or the “Company”), today announced the publication of a review entitled ‘Dupuytren’s disease: a localized and accessible human fibrotic disorder’ in the journal Trends in Molecular Medicine.
In the article, the authors at the University of Oxford, led by Professor Jagdeep Nanchahal, chairman of the medical advisory board of 180 Life Sciences, describe the biology of Dupuytren’s disease, to which they have made important contributions, recognized for example by the International Dupuytren Award in 2019, 2020 and 2021. The authors describe the genetics of this highly heritable disorder, the cellular mechanisms, the intercellular interactions and the key role of low-grade chronic inflammation in the pathogenesis of the disorder. One of the most important findings is that the mechanisms underlying the development of fibrosis in the hand are very similar to those in internal organs such as the lung in idiopathic pulmonary fibrosis.
Professor Marc Feldmann FRS, co-chairman of 180 Life Sciences said “This review provides an important update on our understanding of molecular basis of Dupuytren’s disease. By unravelling the signaling pathways and demonstrating their link to the genetics, Professor Nanchahal and his colleagues identified tumor necrosis factor (TNF) as a therapeutic target in the laboratory and went on to demonstrate the efficacy of anti-TNF for the treatment of early-stage Dupuytren’s disease in a phase 2b clinical trial, the results which have been previously announced. Importantly, they have recently shown that anti-TNF treatment could also be cost-effective.”
Dr. James Woody, CEO of 180 Life Sciences, stated, “Treatment of early-stage Dupuytren’s disease represents a huge unmet medical need, and at 180 Life Sciences we are delighted to be advancing the pioneering work of Prof Nanchahal and his team who are developing the use of anti-TNF (adalimumab) hopefully for the benefit of the millions of patients affected by early-stage Dupuytren’s disease, for which there is no approved treatment.”
About 180 Life Sciences Corp.
180 Life Sciences Corp. is a clinical-stage biotechnology company driving ground-breaking studies into clinical programs which are seeking to address major unmet medical needs. The Company’s focus is a novel program to treat several inflammatory disorders using anti-TNF (tumor necrosis factor).
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180 Life Sciences Corp